Journal article
Hyperandrogenism and Metabolic Syndrome Are Associated With Changes in Serum-Derived microRNAs in Women With Polycystic Ovary Syndrome
AE Sørensen, PB Udesen, G Maciag, J Geiger, N Saliani, AS Januszewski, G Jiang, RC Ma, AA Hardikar, MLM Wissing, ALM Englund, LT Dalgaard
Frontiers in Medicine | FRONTIERS MEDIA SA | Published : 2019
Abstract
Polycystic ovary syndrome (PCOS) remains one of the most common endocrine disorder in premenopausal women with an unfavorable metabolic risk profile. Here, we investigate whether biochemical hyperandrogenism, represented by elevated serum free testosterone, resulted in an aberrant circulating microRNA (miRNAs) expression profile and whether miRNAs can identify those PCOS women with metabolic syndrome (MetS). Accordingly, we measured serum levels of miRNAs as well as biochemical markers related to MetS in a case-control study of 42 PCOS patients and 20 Controls. Patients were diagnosed based on the Rotterdam consensus criteria and stratified based on serum free testosterone levels (≥0.034 nmo..
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Awarded by Danish Diabetes Academy
Funding Acknowledgements
This study was supported by a Merck Serono Grant for Fertility Innovation to MW, AE, and LD, a doctoral research grant from the Danish Diabetes Academy supported by the Novo Nordisk Foundation and from Roskilde University to AS, and grants from Region Zealand (Region Sjaellands Forskningsfond) to PU and AE. Grants from ReproUnion, co-financed by European Union and Interreg program V Oresund-Kattegat-Skagerak to PU. An EFSD Albert Renold travel fellowship to NS and AS. The Postdoctoral Fellowship Scheme from the Chinese University of Hong Kong and RGC General Research Fund (ref. 14110415) to GJ and RM. A JDRF Australia Career Development Fellowship and a visiting professorship from the Danish Diabetes Academy to AH. The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript.