Journal article

Microbial regulation of natural antibiotic resistance: Understanding the protist-bacteria interactions for evolution of soil resistome

Bao-Anh Thi Nguyen, Qing-Lin Chen, Ji-Zheng He, Hang-Wei Hu

Science of The Total Environment | Elsevier BV | Published : 2020

Abstract

The emergence, evolution and spread of antibiotic resistance genes (ARGs) in the environment represent a global threat to human health. Our knowledge of antibiotic resistance in human-impacted ecosystems is rapidly growing with antibiotic use, organic fertilization and wastewater irrigation identified as key selection pressures. However, the importance of biological interactions, especially predation and competition, as a potential driver of antibiotic resistance in the natural environment with limited anthropogenic disturbance remains largely overlooked. Stress-affected bacteria develop resistance to maximize competition and survival, and similarly bacteria may develop resistance to fight s..

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