Journal article

Early life microbial exposure, child neurocognition and behaviour at 2 years of age: A birth cohort study

Elizabeth Senn, Christos Symeonides, Peter Vuillermin, Anne-Louise Ponsonby, John Carlin, Mimi Tang, Fiona Collier, Terry Dwyer, Sarath Ranganathan, Peter Sly, Len Harrison, David Burgner



AIM: To investigate the relationship between factors which influence external microbial exposures (FEMEs), previously identified to be protective or to increase the risk of the development of allergic disease, and cognition and behaviour in infants 2 years of age in an Australian population. METHOD: The Barwon Infant Study is a birth cohort (n = 1074) in Victoria, Australia. Comprehensive questionnaire, clinical and biological measures were collected at multiple time oints. Multiple linear regression was used to evaluate the associations between 56 FEMEs and 3 outcomes; cognition (Bayley Scales of Infant and Toddler Development (BAYLEY-III)) (n = 667, mean (standard deviation) age = 2.45 (0...

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Funding Acknowledgements

The authors thank the BIS participants for the generous contribution they have made to this project. The authors also thank current and past staff for their efforts in recruiting and maintaining the cohort and in obtaining and processing the data and biospecimens. The establishment work and infrastructure for the BIS was provided by the Murdoch Children's Research Institute, Deakin University and Barwon Health. Subsequent funding was secured from the National Health and Medical Research Council of Australia (NHMRC), The Shepherd Foundation, The Jack Brockhoff Foundation, the Scobie Trust, the Shane O'Brien Memorial Asthma Foundation, the OurWomen's Our Children's Fund Raising Committee Barwon Health, the Rotary Club of Geelong, the Ilhan Food Allergy Foundation, GMHBA and the Percy Baxter Charitable Trust, Perpetual Trustees. In-kind support was provided by the Cotton on Foundation and CreativeForce. Research at Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. C Symeonides is supported by a NHMRC PhD scholarship. AL Ponsonby and P Sly receive NHMRC fellowship support. E Senn is supported by Australian Rotary Health (Terry Orr Memorial Scholarship), Vanguard and Murdoch Children's Research Institute.