Journal article

Chronic voluntary alcohol consumption causes persistent cognitive deficits and cortical cell loss in a rodent model

Annai J Charlton, Carlos May, Sophia J Luikinga, Emma L Burrows, Jee Hyun Kim, Andrew J Lawrence, Christina J Perry

SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2019

Abstract

Chronic alcohol use is associated with cognitive decline that impedes behavioral change during rehabilitation. Despite this, addiction therapy does not address cognitive deficits, and there is poor understanding regarding the mechanisms that underlie this decline. We established a rodent model of chronic voluntary alcohol use to measure ensuing cognitive effects and underlying pathology. Rats had intermittent access to alcohol or an isocaloric solution in their home cage under voluntary 2-bottle choice conditions. In Experiments 1 and 2 cognition was assessed using operant touchscreen chambers. We examined performance in a visual discrimination and reversal task (Experiment 1), and a 5-choic..

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Grants

Awarded by National Health and Medical Research Council (NHMRC)/Australian Research Council (ARC) Dementia Research Development Fellowship


Awarded by NHMRC/ARC Dementia Research Development Fellowship


Awarded by NHMRC


Funding Acknowledgements

We would like to thank Dr Samantha Barton for her advice on how to measure activation state of microglia, and to Dr Mikhail Trubetskov and Dr Carolina Chavez for their invaluable assistance in seeking out a program that would calculate effective thresholds using the images taken. We would also like to thank Dr Tanawan Leeboonngam and Ms Hannah Miller for their assistance in collecting behavioral data. This work was supported by National Health and Medical Research Council (NHMRC)/Australian Research Council (ARC) Dementia Research Development Fellowship 1107144 (CJP), NHMRC/ARC Dementia Research Development Fellowship 1111552 (EB), NHMRC project grant 1161316 (AJL, CJP) and 1063140 (JHK, AJL), NHMRC Principal Research Fellowship 1116930 (AJL), NHMRC Career Development Fellowship 1083309 (JHK), and the Victorian State Government Operational Infrastructure Scheme.