Journal article

Distribution and Prognostic Significance of Left Ventricular Global Longitudinal Strain in Asymptomatic Significant Aortic Stenosis An Individual Participant Data Meta-Analysis

Julien Magne, Bernard Cosyns, Bogdan A Popescu, Helle G Carstensen, Jordi Dahl, Milind Y Desai, Leighton Kearney, Patrizio Lancellotti, Thomas H Marwick, Kimi Sato, Masaaki Takeuchi, Concetta Zito, Anne-Claire Casalta, Dania Mohty, Luc Pierard, Gilbert Habib, Erwan Donal



OBJECTIVES: In this individual participant data meta-analysis on left ventricular global longitudinal strain (LVGLS), our objective was to: 1) describe its distribution; 2) identify the most predictive cutoff values; and 3) assess its impact on mortality in asymptomatic patients with significant aortic stenosis (AS) and preserved left ventricular ejection fraction (LVEF). BACKGROUND: The evidence supporting the prognostic role of LVGLS in asymptomatic patients with AS has been obtained from several relatively small studies. METHODS: A literature search was performed for studies published between 2005 and 2017 without language restriction according to the following criteria: "aortic stenosis"..

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