Journal article
The evolution and genetic diversity of avian influenza A(H9N2) viruses in Cambodia, 2015 – 2016
A Suttie, S Tok, S Yann, P Keo, SV Horm, M Roe, M Kaye, S Sorn, D Holl, S Tum, IG Barr, AC Hurt, AR Greenhill, EA Karlsson, D Vijaykrishna, YM Deng, P Dussart, PF Horwood
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2019
Abstract
Low pathogenic A(H9N2) subtype avian influenza viruses (AIVs) were originally detected in Cambodian poultry in 2013, and now circulate endemically. We sequenced and characterised 64 A(H9N2) AIVs detected in Cambodian poultry (chickens and ducks) from January 2015 to May 2016. All A(H9) viruses collected in 2015 and 2016 belonged to a new BJ/94like h9-4.2.5 sub-lineage that emerged in the region during or after 2013, and was distinct to previously detected Cambodian viruses. Overall, there was a reduction of genetic diversity of H9N2 since 2013, however two genotypes were detected in circulation, P and V, with extensive reassortment between the viruses. Phylogenetic analysis showed a close re..
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Awarded by U.S. Department of Health and Human Services
Funding Acknowledgements
This publication is the result of work conducted under a cooperative agreement with the Office of the Assistant Secretary for Preparedness and Response in the U.S. Department of Health and Human Services (HHS), grant number IDSEP140020-01-00 (PH). The study was also funded, in part, by the US Agency for International Development (grant No. AID-442-G-14-00005) (PH). The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health (IB). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.