Journal article

Mutations in neuroligin-3 in male mice impact behavioral flexibility but not relational memory in a touchscreen test of visual transitive inference

Rebecca HC Norris, Leonid Churilov, Anthony J Hannan, Jess Nithianantharajah

Molecular Autism | BioMed Central | Published : 2019

Abstract

Cognitive dysfunction including disrupted behavioral flexibility is central to neurodevelopmental disorders such as Autism Spectrum Disorder (ASD). A cognitive measure that assesses relational memory, and the ability to flexibly assimilate and transfer learned information is transitive inference. Transitive inference is highly conserved across vertebrates and disrupted in cognitive disorders. Here, we examined how mutations in the synaptic cell-adhesion molecule neuroligin-3 (Nlgn3) that have been documented in ASD impact relational memory and behavioral flexibility. We first refined a rodent touchscreen assay to measure visual transitive inference, then assessed two mouse models of Nlgn3 dy..

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Grants

Awarded by Australian Research Council


Awarded by National Health and Medical Research Council


Funding Acknowledgements

This work was supported by the Australian Research Council Future Fellowship (FT140101327) to J.N., Australian Postgraduate Research Training Award to R.H.N., and a National Health and Medical Research Council Project Grant (APP1083334).