Journal article

Cardiovascular health and retinal microvascular geometry in Australian 11-12 year-olds

Mengjiao Liu, Kate Lycett, Melissa Wake, Mingguang He, Jessica A Kerr, Richard Saffery, Markus Juonala, Tim Olds, Terry Dwyer, David P Burgner, Tien Yin Wong

MICROVASCULAR RESEARCH | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2020

Abstract

Traditional retinal microvascular parameters (smaller arteriolar and greater venular caliber) are associated with cardiovascular risk factors, pre-clinical vascular phenotypes and clinical cardiovascular events in adults. Although novel retinal microvascular geometric parameters showed analogous associations in adults, less is known whether these parameters are associated with cardiovascular health from childhood. In a population-based cross-sectional study in children (n = 1126, mean age 11.4 years, 50.3% girls), we examined associations of cardiovascular risk factors and pre-clinical arterial phenotypes with retinal geometric parameters. Cardiovascular parameters included body mass index (..

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by Royal Children's Hospital Foundation


Awarded by National Heart Foundation of Australia


Awarded by Financial Markets Foundation for Children


Awarded by NHMRC Early Career Fellowship


Awarded by National Heart Foundation Postdoctoral Fellowship


Awarded by NHMRC Senior Research Fellowship


Awarded by Principal Research Fellowship


Funding Acknowledgements

This work was supported by the Australian National Health and Medical Research Council (NHMRC) Project Grants [1041352, 1109355], The Royal Children's Hospital Foundation [2014-241], Murdoch Children's Research Institute, The University of Melbourne, National Heart Foundation of Australia [100660] and Financial Markets Foundation for Children [2014-055, 2016-310]. ML is supported by a Melbourne Research Scholarship. KL is supported by NHMRC Early Career Fellowship [1091124] and National Heart Foundation Postdoctoral Fellowship [101239]. MJ is supported by Juho Vainio Foundation and federal research grants to Turku University Hospital. MW was supported by NHMRC Senior Research Fellowship [1046518], Principal Research Fellowship [1160906] and Cure Kids New Zealand. DPB is supported by NHMRC Senior Research Fellowship [1064629]. Research at the Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Program. The funding bodies did not play any role in the study other than the generous provision of funds.