Experience-dependent development of visual sensitivity in larval zebrafish
Jiaheng Xie, Patricia R Jusuf, Bang V Bui, Patrick T Goodbourn
SCIENTIFIC REPORTS | NATURE PUBLISHING GROUP | Published : 2019
The zebrafish (Danio rerio) is a popular vertebrate model for studying visual development, especially at the larval stage. For many vertebrates, post-natal visual experience is essential to fine-tune visual development, but it is unknown how experience shapes larval zebrafish vision. Zebrafish swim with a moving texture; in the wild, this innate optomotor response (OMR) stabilises larvae in moving water, but it can be exploited in the laboratory to assess zebrafish visual function. Here, we compared spatial-frequency tuning inferred from OMR between visually naïve and experienced larvae from 5 to 7 days post-fertilisation. We also examined development of synaptic connections between neurons ..View full abstract
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Awarded by Discovery Early Career Researcher Award from the Australian Research Council
We thank the Biological Optical Microscopy Platform (BOMP) of the Melbourne Advanced Microscopy Facility for providing instruments for confocal imaging, and Christopher Chia for his assistance in collection of preliminary data. This work was supported by a grant from the Melbourne Neuroscience Institute (to PTG, PRJ & BVB). PTG was supported by a Discovery Early Career Researcher Award from the Australian Research Council (DE160100125).