Celogentin mimetics as inhibitors of tubulin polymerization
Varsha J Thombare, James A Holden, Eric C Reynolds, Neil M O'Brien-Simpson, Craig A Hutton
Journal of Peptide Science | WILEY | Published : 2020
Bicyclic analogues of celogentin C have been synthesized in which the side chain-side chain cross-links are replaced by thioether bonds. Several of the simplified bicyclic peptides displayed potent inhibition of tubulin polymerization.
Related Projects (2)
Awarded by Australian Research Council
Australian Research Council, Grant/Award Numbers: DP150100692 and DP180101804