Journal article

Omega-3 and omega-6 polyunsaturated fatty acids for dry eye disease (Review)

Laura E Downie, Sueko M Ng, Kristina B Lindsley, Esen K Akpek

Cochrane Database of Systematic Reviews | WILEY | Published : 2019


BACKGROUND: Polyunsaturated fatty acid (PUFA) supplements, involving omega-3 and/or omega-6 components, have been proposed as a therapy for dry eye. Omega-3 PUFAs exist in both short- (alpha-linolenic acid [ALA]) and long-chain (eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) forms, which largely derive from certain plant- and marine-based foods respectively. Omega-6 PUFAs are present in some vegetable oils, meats, and other animal products. OBJECTIVES: To assess the effects of omega-3 and omega-6 polyunsaturated fatty acid (PUFA) supplements on dry eye signs and symptoms. SEARCH METHODS: CENTRAL, Medline, Embase, two other databases and three trial registries were searched in Fe..

View full abstract

University of Melbourne Researchers


Awarded by Cochrane Eyes and Vision US Project

Funding Acknowledgements

External sourcesNational Eye Institute, National Institutes of Health, USA.Methodological support provided by the Cochrane Eyes and Vision US Project, which is funded by Grant UG1EY020522National Institute for Health Research (NIHR), UK.Richard Wormald, Co-ordinating Editor for Cochrane Eyes and Vision (CEV) acknowledges financial support for his CEV research sessions from the Department of Health through the award made by the National Institute for Health Research to Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology for a Specialist Biomedical Research Centre for OphthalmologyThis review was supported by the National Institute for Health Research, via Cochrane Infrastructure funding to the CEV UK editorial base