Journal article

Meta-analysis of randomised controlled trials with N-acetylcysteine in the treatment of schizophrenia

Caitlin OB Yolland, Donal Hanratty, Erica Neill, Susan L Rossell, Michael Berk, Olivia M Dean, David J Castle, Eric J Tan, Andrea Phillipou, Anthony WF Harris, Ana Rita Barreiros, Abigail Hansen, Dan Siskind

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY | SAGE PUBLICATIONS LTD | Published : 2019

Abstract

OBJECTIVE: There is accumulating evidence that adjunctive treatment with N-acetylcysteine may be effective for schizophrenia. This study aimed to conduct a comprehensive meta-analysis examining the efficacy of randomised control trials investigating N-acetylcysteine as an adjunct treatment for schizophrenia and the first to investigate cognition as an outcome. METHODS: We systematically reviewed Medline, EmCare, PsycINFO, Embase, CINAHL Complete, China Knowledge Resource Integrated Database and the Cochrane Clinical Trials online registry for randomised control trials of N-acetylcysteine for schizophrenia. We undertook pairwise meta-analyses of N-acetylcysteine vs placebo for psychosis sympt..

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Grants

Awarded by National Health and Medical Research Council


Awarded by NHMRC


Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This project was supported by the National Health and Medical Research Council Project Grant (GNT1098442). S.L.R. holds an NHMRC Senior Research Fellowship (GNT1154651). M.B. is supported by an NHMRC Senior Principal Research Fellowship (GNT1059660 and GNT1156072). E.J.T. holds an NHMRC Early Career Research Fellowship (GNT1142424).