Journal article
Genetic variants in incident SUDEP cases from a community-based prospective cohort with epilepsy
Y Ge, D Ding, G Zhu, P Kwan, W Wang, Z Hong, JW Sander
Journal of Neurology Neurosurgery and Psychiatry | Published : 2019
Abstract
Objective Sudden unexpected death in epilepsy (SUDEP) is a leading cause of epilepsy-related mortality in young adults. It has been suggested that SUDEP may kill over 20 000 people with epilepsy in China yearly. The aetiology of SUDEP is unclear. Little is known about candidate genes for SUDEP in people of Chinese origin as most studies have ascertained this in Caucasians. No candidate genes for SUDEP in Chinese people have been identified. Methods We performed whole exome sequencing (WES) in DNA samples collected from five incident cases of SUDEP identified in a large epilepsy cohort in rural China. We filtered rare variants identified from these cases as well as screened for SUDEP, epileps..
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Awarded by National Institutes of Health
Funding Acknowledgements
This study was funded by Shanghai Municipal Science and Technology Major Project (2018SHZDZX01), Key Research Project of the Chinese Ministry of Science and Technology (2016YFC0904400), a NIH/NINDS grant (1R21NS069223-01) and National Natural Science Foundation of China (81271443). JWS is based at UCLH/UCL Biomedical Research Centre, which receives a proportion of funding from the UK Department of Health's NIHR Research Centres funding scheme. He receives support from the Dr. Marvin Weil Epilepsy Research Fund and UK Epilepsy Society. PK is supported by a Medical Research Future Fund Practitioner Fellowship.