Adoptive cell therapy for melanoma

Abstract

Melanoma is a highly immunogenic cancer, and along with the combination of poor clinical outcomes and treatments with limited efficacy, these attributes have made metastatic melanoma an ideal platform to study immune-based therapies. Adoptive cell therapy (ACT) is as a highly effective personalized cancer treatment, utilizing the natural effector functions of T cells targeting tumor antigens.This chapter will concentrate on the development and efficacy of ACT in melanoma. The chapter reviews the role of the immune system in melanoma, the identification and targeting of specific tumor antigens, and the mechanisms by which tumor cells may evade detection and eradication. The utility of tumor i..