Journal article

Endometrial uNK cell counts do not predict successful implantation in an IVF population

JF Donoghue, P Paiva, WT Teh, LM Cann, C Nowell, H Rees, S Bittinger, V Obers, JN Bulmer, C Stern, J Mcbain, PAW Rogers

HUMAN REPRODUCTION | OXFORD UNIV PRESS | Published : 2019

Abstract

STUDY QUESTION: Are uterine natural killer (uNK) cell numbers and their distribution relative to endometrial arterioles altered in women with recurrent implantation failure (RIF) compared to women with embryo implantation success (IS)? SUMMARY ANSWER: uNK cell numbers and their distribution relative to endometrial arterioles are not significantly different in women with RIF compared to women in whom embryo implantation occurs successfully following IVF. WHAT IS ALREADY KNOWN: uNK cells are regulators of decidual angiogenesis and spiral arteriole remodelling during early pregnancy. Although some studies have shown that uNK cell numbers may be altered in women with RIF, the methods used to mea..

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Grants

Awarded by NHMRC Early Career Fellowship


Awarded by NHMRC Postgraduate Scholarship


Funding Acknowledgements

Funding for this work was provided by Royal Women's Hospital Foundation. P.P. was supported by an NHMRC Early Career Fellowship [TF 11/14] and W.T.T. was supported by an NHMRC Postgraduate Scholarship [1055814]. The authors do not have any competing interests with this study.Funding for this work was provided by Royal Women's Hospital Foundation; P.P. was supported by an NHMRC Early Career Fellowship [TF 11/14] and W.T.T. was supported by an NHMRC Postgraduate Scholarship [#1055814].