Meso-tartrate inhibits intracellular replication of Coxiella burnetii, the causative agent of the zoonotic disease Q fever.
Mebratu A Bitew, Nadeeka K Wawegama, Hayley J Newton, Fiona M Sansom
Pathogens and Disease | Oxford University Press (OUP) | Published : 2019
The zoonotic disease Q fever, caused by the intracellular bacterium Coxiella burnetii, remains a global health threat due to its high infectivity, environmental stability, the debilitating nature of the disease and the long duration of treatment. Designing new and potent drugs that target previously unexplored pathways is essential to shorten treatment time and minimize antibiotic resistance. Nicotinamide adenine dinucleotide (NAD) is an essential and ubiquitous cofactor in all living organisms. NadB, an L-aspartate oxidase catalysing the first step of the prokaryotic-specific NAD de novo biosynthetic pathway, is required for C. burnetii growth and replication inside host cells. In this stud..View full abstract