Journal article

Renal hemodynamics and oxygenation during experimental cardiopulmonary bypass in sheep under total intravenous anesthesia

Roger G Evans, Naoya Iguchi, Andrew D Cochrane, Bruno Marino, Sally G Hood, Rinaldo Bellomo, Peter R McCall, Clive N May, Yugeesh R Lankadeva

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology | AMER PHYSIOLOGICAL SOC | Published : 2020


Renal medullary hypoxia may contribute to the pathophysiology of acute kidney injury, including that associated with cardiac surgery requiring cardiopulmonary bypass (CPB). When performed under volatile (isoflurane) anesthesia in sheep, CPB causes renal medullary hypoxia. There is evidence that total intravenous anesthesia (TIVA) may preserve renal perfusion and renal oxygen delivery better than volatile anesthesia. Therefore, we assessed the effects of CPB on renal perfusion and oxygenation in sheep under propofol/fentanyl-based TIVA. Sheep (n = 5) were chronically instrumented for measurement of whole renal blood flow and cortical and medullary perfusion and oxygenation. Five days later, t..

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Awarded by National Health and Medical Research Council of Australia

Awarded by National Heart Foundation of Australia

Funding Acknowledgements

This work was supported by National Health and Medical Research Council of Australia Grant GNT1122455, Victorian Government Operational Infrastructure Support Grant, and National Heart Foundation of Australia Grant NHF-101853.