Journal article

Co-existence of Network Architectures Supporting the Human Gut Microbiome

Caitlin Hall, Anton Lord, Richard Betzel, Martha Zakrzewski, Lisa A Simms, Andrew Zalesky, Graham Radford-Smith, Luca Cocchi

ISCIENCE | CELL PRESS | Published : 2019

Abstract

Microbial organisms of the human gut microbiome do not exist in isolation but form complex and diverse interactions to maintain health and reduce risk of disease development. The organization of the gut microbiome is assumed to be a singular assortative network, where interactions between operational taxonomic units (OTUs) can readily be clustered into segregated and distinct communities. Here, we leverage recent methodological advances in network modeling to assess whether communities in the human microbiome exhibit a single network structure or whether co-existing mesoscale network architectures are present. We found evidence for core-periphery structures in the microbiome, supported by st..

View full abstract

University of Melbourne Researchers

Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by NHMRC


Funding Acknowledgements

We thank S. Sonkusare for helpful feedback on the early version of the manuscript. L.C. would like to acknowledge support from the Australian National Health and Medical Research Council (NHMRC), APP1099082. A. Z. was supported by an NHMRC Senior Research Fellowship B, ID:1136649.