Co-existence of Network Architectures Supporting the Human Gut Microbiome
Caitlin Hall, Anton Lord, Richard Betzel, Martha Zakrzewski, Lisa A Simms, Andrew Zalesky, Graham Radford-Smith, Luca Cocchi
ISCIENCE | CELL PRESS | Published : 2019
Microbial organisms of the human gut microbiome do not exist in isolation but form complex and diverse interactions to maintain health and reduce risk of disease development. The organization of the gut microbiome is assumed to be a singular assortative network, where interactions between operational taxonomic units (OTUs) can readily be clustered into segregated and distinct communities. Here, we leverage recent methodological advances in network modeling to assess whether communities in the human microbiome exhibit a single network structure or whether co-existing mesoscale network architectures are present. We found evidence for core-periphery structures in the microbiome, supported by st..View full abstract
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Awarded by Australian National Health and Medical Research Council (NHMRC)
Awarded by NHMRC
We thank S. Sonkusare for helpful feedback on the early version of the manuscript. L.C. would like to acknowledge support from the Australian National Health and Medical Research Council (NHMRC), APP1099082. A. Z. was supported by an NHMRC Senior Research Fellowship B, ID:1136649.