Journal article

Reducing socio-economic inequalities in all-cause mortality: A counterfactual mediation approach

JE Laine, VT Baltar, S Stringhini, M Gandini, M Chadeau-Hyam, M Kivimaki, G Severi, V Perduca, AM Hodge, PA Dugué, GG Giles, RL Milne, H Barros, C Sacerdote, V Krogh, S Panico, R Tumino, M Goldberg, M Zins, C Delpierre

International Journal of Epidemiology | OXFORD UNIV PRESS | Published : 2021

Abstract

Background: Socio-economic inequalities in mortality are well established, yet the contribution of intermediate risk factors that may underlie these relationships remains unclear. We evaluated the role of multiple modifiable intermediate risk factors underlying socio- economic-associated mortality and quantified the potential impact of reducing early allcause mortality by hypothetically altering socio-economic risk factors. Methods: Data were from seven cohort studies participating in the LIFEPATH Consortium (total n 179 090). Using both socio-economic position (SEP) (based on occupation) and education, we estimated the natural direct effect on all-cause mortality and the natural indirect ef..

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