IL-17( ) CD8( ) T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis

Christina Lueckel; Felix Picard; Hartmann Raifer; Lucia Campos Carrascosa; Anna Guralnik; Yajuan Zhang; Matthias Klein; Stefan Bittner; Falk Steffen; Sonja Moos; Federico Marini; Renee Gloury; Florian C Kurschus; Ying-Yin Chao; Wilhelm Bertrams; Veronika Sexl; Bernd Schmeck; Lynn Bonetti; Melanie Grusdat; Michael Lohoff; Christina E Zielinski; Frauke Zipp; Axel Kallies; Dirk Brenner; Michael Berger; Tobias Bopp; Bjoern Tackenberg; Magdalena Huber

Journal article

IL-17( ) CD8( ) T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis

Christina Lueckel, Felix Picard, Hartmann Raifer, Lucia Campos Carrascosa, Anna Guralnik, Yajuan Zhang, Matthias Klein, Stefan Bittner, Falk Steffen, Sonja Moos, Federico Marini, Renee Gloury, Florian C Kurschus, Ying-Yin Chao, Wilhelm Bertrams, Veronika Sexl, Bernd Schmeck, Lynn Bonetti, Melanie Grusdat, Michael Lohoff Show all

Nature Communications | NATURE PUBLISHING GROUP | Published : 2019

DOI: 10.1038/s41467-019-13731-z

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University of Melbourne Researchers

Axel Kallies Author Microbiology and Immunology

Renee Gloury Author Microbiology and Immunology

Grants

Awarded by Biogen

Awarded by UKGM

Awarded by DFG

Awarded by Fresenius Stiftung

Awarded by GIF

Awarded by e:Med

Awarded by JPIAMR Restrict-Pneumo-AMR

Awarded by LOEWE Medical-RNomics

Awarded by FNR-PRIDE

Awarded by German Federal Ministry of Education and Research

Awarded by FNR-ATTRACT

Awarded by FNR-CORE

Funding Acknowledgements

We thank Dr. Finkernagel, Dr. Green, Dr. Dolga, Dr. Jastroch, Dr. Bauer, Dr. Garn, M.Sc. Vogel, B.Sc. Erlemann, B.Sc. Kolbl, M.Sc. Ruhe, Mr. Happel, B.Sc. Girschik for experimental support. This work was supported by Biogen IIT-GER_BGT-13_10580 (M. H.;B.T.), UKGM 10/2016 (M.H.), DFG HU 1824/7-1 (M.H.), Fresenius Stiftung, 2015_A232 (M.H.), GIF I-1474-414.13/2018 M.H., M.B.), SFB/TR-128 (S.B.,F.Z.,F.C.K., T.B.), and SFB/TR-156 (F.C.K.); e:Med CAPSYS-FKZ01ZX1304E, JPIAMR Restrict-Pneumo-AMR - FKZ 01Kl1702 (B.S), SFB/TR-84 C1 (B.S), LOEWE Medical-RNomicsFKZ 519/03/00.001-(0003) (B.S); D.B. and L.B. are funded by FNR-PRIDE (PRIDE/11012546/NEXTIMMUNE), FNR-ATTRACT (A14/BM/7632103) and FNR-CORE (C15/BM/10355103); National Health and Medical Research Council (NHMRC) and Sylvia and Charles Viertel Foundation (A.K.); German Federal Ministry of Education and Research (BMBF 01EO1003). This study was investigator initiated and funded by an unrestricted grant of Biogen, the manufacturer of dimethyl fumarate (Tecfidera). Biogen was not involved in data storage, data analysis or data interpretation. Biogen was informed about the results and was neither involved in the submission, nor the publication of the paper.