The double burden of malnutrition: aetiological pathways and consequences for health
Jonathan C Wells, Ana Lydia Sawaya, Rasmus Wibaek, Martha Mwangome, Marios S Poullas, Chittaranjan S Yajnik, Alessandro Demaio
LANCET | ELSEVIER SCIENCE INC | Published : 2020
Malnutrition has historically been researched and addressed within two distinct silos, focusing either on undernutrition, food insecurity, and micronutrient deficiencies, or on overweight, obesity, and dietary excess. However, through rapid global nutrition transition, an increasing proportion of individuals are exposed to different forms of malnutrition during the life course and have the double burden of malnutrition (DBM) directly. Long-lasting effects of malnutrition in early life can be attributed to interconnected biological pathways, involving imbalance of the gut microbiome, inflammation, metabolic dysregulation, and impaired insulin signalling. Life-course exposure to early undernut..View full abstract
Funding for the preparation of the Series was provided by WHO, through a grant from the Bill & Melinda Gates Foundation. The funder had no role in the analysis and interpretation of the evidence or in writing the paper and the decision to submit for publication.