Predominantly Antibody-Deficient Patients With Non-infectious Complications Have Reduced Naive B, Treg, Th17, and Tfh17 Cells
Emily SJ Edwards, Julian J Bosco, Pei M Aui, Robert G Stirling, Paul U Cameron, Josh Chatelier, Fiona Hore-Lacy, Robyn E O'Hehir, Menno C van Zelm
FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2019
Background: Patients with predominantly antibody deficiency (PAD) suffer from severe and recurrent infections that require lifelong immunoglobulin replacement and prophylactic antibiotic treatment. Disease incidence is estimated to be 1:25,000 worldwide, and up to 68% of patients develop non-infectious complications (NIC) including autoimmunity, which are difficult to treat, causing high morbidity, and early mortality. Currently, the etiology of NIC is unknown, and there are no diagnostic and prognostic markers to identify patients at risk. Objectives: To identify immune cell markers that associate with NIC in PAD patients. Methods: We developed a standardized 11-color flow cytometry panel t..View full abstract
Awarded by Australian National Health and Medical Research Council (NHMRC)
This work was supported by the Australian National Health and Medical Research Council (NHMRC; Senior Research Fellowship 1117687 for MZ) and the Jeffrey Modell Foundation.