Journal article

Nitric Oxide Resistance, Induced in the Myocardium by Diabetes, Is Circumvented by the Nitric Oxide Redox Sibling, Nitroxyl.

Cheng Xue Qin, Jarryd Anthonisz, Chen Huei Leo, Nicola Kahlberg, Anida Velagic, Mandy Li, Edwina Jap, Owen L Woodman, Laura J Parry, John D Horowitz, Barbara K Kemp-Harper, Rebecca H Ritchie

Antioxidants and Redox Signaling | Mary Ann Liebert | Published : 2020

Abstract

Aim: Impairment of tissue responsiveness to exogenous and endogenous nitric oxide (NO•), known as NO• resistance, occurs in many cardiovascular disease states, prominently in diabetes and especially in the presence of marked hyperglycemia. In this study, we sought to determine in moderate and severe diabetes (i) whether NO• resistance also occurs in the myocardium, and (ii) whether the NO• redox sibling nitroxyl (HNO) circumvents this. Results: The spectrum of acute NO• effects (induced by diethylamine-NONOate), including vasodilation, and enhanced myocardial contraction and relaxation were impaired by moderately diabetic rats ([blood glucose] ∼20 mM). In contrast, acute HNO effects (induce..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by Diabetes Australia Research Trust


Funding Acknowledgements

This work was supported in part by both the National Health and Medical Research Council (NHMRC) of Australia, including APP1045140 (to R.H.R. J.D.H. and B.K.K.), APP1064845 (to L.J.P.), Diabetes Australia Research Trust Y13M1-RITR (to R.H.R and B.K.K.), and the Victorian Government's Operational Infrastructure Support Program. R.H.R. is an NHMRC Senior Research Fellow(APP1059960). N.K. received a Melbourne Research Scholarship.