Journal article

Basic symptoms in young people at ultra-high risk of psychosis: Association with clinical characteristics and outcomes

S Youn, LJ Phillips, GP Amminger, G Berger, EYH Chen, L de Haan, JA Hartmann, IB Hickie, S Lavoie, C Markulev, PD McGorry, N Mossaheb, DH Nieman, M Nordentoft, A Riecher-Rossler, MR Schafer, M Schloegelhofer, S Smesny, A Thompson, S Verma Show all

Schizophrenia Research | ELSEVIER | Published : 2020

Abstract

There has been limited research into the predictive value of basic symptoms and their relationship with other psychopathology in patients identified using the 'ultra high risk' (UHR) for psychosis approach. The current study investigated whether basic symptoms, specifically cognitive disturbances (COGDIS), were associated with a greater risk of transition to psychotic disorder and persistent attenuated psychotic symptoms (APS) at medium term follow-up (mean = 3.4 years) in UHR patients, as well as with general psychopathology at baseline. The sample included 304 UHR participants (mean age = 19.12 years) involved in an international multicenter trial of omega-3 fatty acids. UHR individuals wh..

View full abstract

Grants

Awarded by Stanley Medical Research Institute


Awarded by National Health and Medical Research Council (NHMRC) Australia


Awarded by NHMRC


Funding Acknowledgements

This work was supported by a grant from the Stanley Medical Research Institute (07TGF-1102), a National Health and Medical Research Council (NHMRC) Australia Program Grant (ID: 566529; P.D.M., I.B.H., A.R.Y., and G.P.A.), and a grant from the Colonial Foundation. P.D.M. was supported by a Senior Principal Research Fellowship from the NHMRC (ID: 1060996). G.P.A., A.R.Y., and BN were supported by NHMRC Senior Research Fellowships (IDs: 1080963, 566593, 1137687). J.A.H. was supported by a University of Melbourne McKenzie Fellowship. We thank the study participants and Research Assistants and also the anonymous reviewers for making suggestions to improve the quality of the manuscript.