Cumulative Burden of Colorectal Cancer Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer

Alexi N Archambault; Yu-Ru Su; Jihyoun Jeon; Minta Thomas; Yi Lin; David V Conti; Aung Ko Win; Lori C Sakoda; Iris Lansdorp-Vogelaar; Elisabeth FP Peterse; Ann G Zauber; David Duggan; Andreana N Holowatyj; Jeroen R Huyghe; Hermann Brenner; Michelle Cotterchio; Stephane Bezieau; Stephanie L Schmit; Christopher K Edlund; Melissa C Southey; Robert J MacInnis; Peter T Campbell; Jenny Chang-Claude; Martha L Slattery; Andrew T Chan; Amit D Joshi; Mingyang Song; Yin Cao; Michael O Woods; Emily White; Stephanie J Weinstein; Cornelia M Ulrich; Michael Hoffmeister; Stephanie A Bien; Tabitha A Harrison; Jochen Hampe; Christopher I Li; Clemens Schafmayer; Kenneth Offit; Paul D Pharoah; Victor Moreno; Annika Lindblom; Alicja Wolk; Anna H Wu; Li Li; Marc J Gunter; Andrea Gsur; Temitope O Keku; Rachel Pearlman; D Timothy Bishop; Sergi Castellvi-Bel; Leticia Moreira; Pavel Vodicka; Ellen Kampman; Graham G Giles; Demetrius Albanes; John A Baron; Sonja I Berndt; Stefanie Brezina; Stephan Buch; Daniel D Buchanan; Antonia Trichopoulou; Gianluca Severi; Maria-Dolores Chirlaque; Maria-Jose Sanchez; Domenico Palli; Tilman Kuhn; Neil Murphy; Amanda J Cross; Andrea N Burnett-Hartman; Stephen J Chanock; Albert de la Chapelle; Douglas F Easton; Faye Elliott; Dallas R English; Edith JM Feskens; Liesel M FitzGerald; Phyllis J Goodman; John L Hopper; Thomas J Hudson; David J Hunter; Eric J Jacobs; Corinne E Joshu; Sebastien Kury; Sanford D Markowitz; Roger L Milne; Elizabeth A Platz; Gad Rennert; Hedy S Rennert; Fredrick R Schumacher; Robert S Sandler; Daniela Seminara; Catherine M Tangen; Stephen N Thibodeau; Amanda E Toland; Franzel JB van Duijnhoven; Kala Visvanathan; Ludmila Vodickova; John D Potter; Satu Mannisto; Korbinian Weigl; Jane Figueiredo; Vicente Martin; Susanna C Larsson; Patrick S Parfrey; Wen-Yi Huang; Heinz-Josef Lenz; Jose E Castelao; Manuela Gago-Dominguez; Victor Munoz-Garzon; Christoph Mancao; Christopher A Haiman; Lynne R Wilkens; Erin Siegel; Elizabeth Barry; Ban Younghusband; Bethany Van Guelpen; Sophia Harlid; Anne Zeleniuch-Jacquotte; Peter S Liang; Mengmeng Du; Graham Casey; Noralane M Lindor; Loic Le Marchand; Steven J Gallinger; Mark A Jenkins; Polly A Newcomb; Stephen B Gruber; Robert E Schoen; Heather Hampel; Douglas A Corley; Li Hsu; Ulrike Peters; Richard B Hayes

Journal article

Cumulative Burden of Colorectal Cancer Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset Cancer

Alexi N Archambault, Yu-Ru Su, Jihyoun Jeon, Minta Thomas, Yi Lin, David V Conti, Aung Ko Win, Lori C Sakoda, Iris Lansdorp-Vogelaar, Elisabeth FP Peterse, Ann G Zauber, David Duggan, Andreana N Holowatyj, Jeroen R Huyghe, Hermann Brenner, Michelle Cotterchio, Stephane Bezieau, Stephanie L Schmit, Christopher K Edlund, Melissa C Southey Show all

GASTROENTEROLOGY | W B SAUNDERS CO-ELSEVIER INC | Published : 2020

DOI: 10.1053/j.gastro.2019.12.012

Abstract

BACKGROUND & AIMS: Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence; yet, in the absence of a family history of CRC, this population lacks harmonized recommendations for prevention. We aimed to determine whether a polygenic risk score (PRS) developed from 95 CRC-associated common genetic risk variants was associated with risk for early-onset CRC. METHODS: We studied risk for CRC associated with a weighted PRS in 12,197 participants younger than 50 years old vs 95,865 participants 50 years or older. PRS was calculated based on single nucleotide polymorphisms associated with CRC in a large-scale genome-wide association study as of January 201..

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