Journal article

Reproductive and Hormonal Factors and Risk of Ovarian Cancer by Tumor Dominance: Results from the Ovarian Cancer Cohort Consortium (OC3)

Tianyi Huang, Mary K Townsend, Nicolas Wentzensen, Britton Trabert, Emily White, Alan A Arslan, Elisabete Weiderpass, Julie E Buring, Tess V Clendenen, Graham G Giles, I-Min Lee, Roger L Milne, N Charlotte Onland-Moret, Ulrike Peters, Dale P Sandler, Leo J Schouten, Piet A van den Brandt, Alicja Wolk, Anne Zeleniuch-Jacquotte, Shelley S Tworoger



BACKGROUND: Laterality of epithelial ovarian tumors may reflect the underlying carcinogenic pathways and origins of tumor cells. METHODS: We pooled data from 9 prospective studies participating in the Ovarian Cancer Cohort Consortium. Information on measures of tumor size or tumor dominance was extracted from surgical pathology reports or obtained through cancer registries. We defined dominant tumors as those restricted to one ovary or where the dimension of one ovary was at least twice as large as the other, and nondominant tumors as those with similar dimensions across the two ovaries or peritoneal tumors. Competing risks Cox models were used to examine whether associations with reproducti..

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Awarded by Department of Defense Ovarian Cancer Research Program

Awarded by Australian National Health and Medical Research Council

Awarded by NIEHS Intramural Research Program

Awarded by NCI

Funding Acknowledgements

The authors acknowledge the Channing Division of Network Medicine, Department of Medicine, Brigham andWomen's Hospital (Boston, MA), as the home of the Nurses' Health Study. The Nurses' Health Study would like to thank the following state cancer registries for their assistance: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA, WY. This work was supported by Department of Defense Ovarian Cancer Research Program grant W81XWH-12-1-0561 (to S.S. Tworoger). Additional research funding and support included NCI Intramural Research Program; VicHealth and Cancer Council Victoria, and Australian National Health and Medical Research Council grants 209057, 396414, and 1074383 (Melbourne Collaborative Cohort Study); UM1 CA186107, P01 CA87969 (Nurses' Health Study); UM1 CA176726 (Nurses' Health Study II); UM1 CA182934, P30 CA016087 and P30 ES000260 (NYU Women's Health Study); NIEHS Intramural Research Program (Sisters Study, Project Z01-ES044005 to D.P. Sandler); Swedish Cancer Foundation (Swedish Mammography Cohort); K05CA154337 from theNCI andOffice of Dietary Supplements (VITamins And Lifestyle Cohort); and CA047988, HL043851, HL080467, HL099355, and CA182913 (Women's Health Study).