Journal article

Examining Microstructural White Matter Differences between Children with Typical and Those with Delayed Recovery Two Weeks Post-Concussion

Jesse S Shapiro, Tim Silk, Michael Takagi, Nicholas Anderson, Cathriona Clarke, Gavin A Davis, Kevin Dunne, Stephen JC Hearps, Vera Ignjatovic, Vanessa Rausa, Marc Seal, Franz E Babl, Vicki Anderson

Journal of Neurotrauma | MARY ANN LIEBERT, INC | Published : 2020

Abstract

Delayed recovery from concussion can dramatically affect a child's social, emotional, and educational development, yet little is known about what causes some children to recover faster than others. The contribution of white matter disruption in children with delayed recovery has been hypothesized, but findings are limited by methodological issues such as: small heterogeneous samples, bias toward children with delayed recovery, and inconsistencies in timing of brain imaging, both within and between studies. The aim of the present study was to assess diffusion neuroimaging correlates of delayed recovery post-concussion in children. A prospective, longitudinal, observational cohort study was co..

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Grants

Awarded by Royal Children's Hospital Foundation, Melbourne, Australia


Awarded by NHMRC


Funding Acknowledgements

The study is funded by a project grant from Royal Children's Hospital Foundation, Melbourne, Australia (2014-370) and nearmiss funding from the Clinical Sciences Theme, MCRI. Dr. Babl was funded by the Royal Children's Hospital Research Foundation, an NHMRC Practitioner Fellowship GNT 1127542, and a Melbourne Campus Clinician Scientist Fellowship; and Dr. Anderson was funded by an NHMRC Senior Practitioner Fellowship GNT 1079478. The funding organizations did not have a role in the design or conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication.