Journal article

Insights from clinical research completed during the west Africa Ebola virus disease epidemic

Amanda Rojek, Peter Horby, Jake Dunning

The Lancet Infectious Diseases | ELSEVIER SCI LTD | Published : 2017


The west Africa Ebola virus disease (EVD) epidemic was extraordinary in scale. Now that the epidemic has ended, it is a relevant time to examine published studies with direct relevance to clinical care and, more broadly, to examine the implications of the clinical research response mounted. Clinically relevant research includes literature detailing risk factors for and clinical manifestations of EVD, laboratory and other investigation findings in patients, experimental vaccine and therapeutic clinical trials, and analyses of survivor syndrome. In this Review, we discuss new insights from patient-oriented research completed during the west Africa epidemic, identify ongoing knowledge gaps, and..

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University of Melbourne Researchers


Awarded by Wellcome Trust of Great Britain

Awarded by EU FP7 project PREPARE

Awarded by UK Medical Research Council

Awarded by Bill & Melinda Gates Foundation

Funding Acknowledgements

AR is funded by a Rhodes Scholarship. The authors would like to thank Adrian Hill and Simon Mendelsohn at the University of Oxford for their advice on the review of vaccine progress. This work was supported by the Wellcome Trust of Great Britain (grant numbers 107834/Z/15/Z and106491/Z/14/Z), EU FP7 project PREPARE (602525), UK Medical Research Council (MC_PC_15001), and the Bill & Melinda Gates Foundation (OPP1116588).