A systematic review and meta-analysis of patient data from the West Africa (2013-16) Ebola virus disease epidemic
AM Rojek, A Salam, RJ Ragotte, E Liddiard, A Elhussain, A Carlqvist, M Butler, N Kayem, L Castle, L 'O Odondi, K Stepniewska, PW Horby
Clinical Microbiology and Infection | ELSEVIER SCI LTD | Published : 2019
BACKGROUND: Over 28 000 individuals were infected with Ebola virus during the West Africa (2013-2016) epidemic, yet there has been criticism of the lack of robust clinical descriptions of Ebola virus disease (EVD) illness from that outbreak. OBJECTIVES: To perform a meta-analysis of published data from the epidemic to describe the clinical presentation, evolution of disease, and predictors of mortality in individuals with EVD. To assess the quality and utility of published data for clinical and public health decision-making. DATA SOURCES: Primary articles available in PubMed and published between January 2014 and May 2017. ELIGIBILITY: Studies that sequentially enrolled individuals hospitali..View full abstract
Awarded by Wellcome Trust of Great Britain
This report is independent research funded and undertaken by the UK Public Health Rapid Support Team, which is funded by the UK Government. The views expressed in this publication are those of the author(s) and not necessarily those of the National Health Service, the National Institute for Health Research or the Department of Health. This work was supported by theWellcome Trust of Great Britain (grant numbers 107834/Z/15/Z and 106491/Z/14/Z). AR was funded by a Rhodes Scholarship. The funders had no role in the study design, the collection, analysis and interpretation of data, in the writing of the report, or in the decision to submit the paper for publication.