Journal article

A systematic review of clinical guidelines on the management of acute, community-acquired CNS infections

Louise Sigfrid, Chelsea Perfect, Amanda Rojek, Kajsa-Stina Longuere, Sam Lipworth, Eli Harriss, James Lee, Alex Salam, Gail Carson, Herman Goossens, Peter Horby

BMC Medicine | BMC | Published : 2019


BACKGROUND: The epidemiology of CNS infections in Europe is dynamic, requiring that clinicians have access to up-to-date clinical management guidelines (CMGs) to aid identification of emerging infections and for improving quality and a degree of standardisation in diagnostic and clinical management practices. This paper presents a systematic review of CMGs for community-acquired CNS infections in Europe. METHODS: A systematic review. Databases were searched from October 2004 to January 2019, supplemented by an electronic survey distributed to 115 clinicians in 33 European countries through the CLIN-Net clinical network of the COMBACTE-Net Innovative Medicines Initiative. Two reviewers screen..

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University of Melbourne Researchers


Awarded by European Commission's FP7 Programme

Funding Acknowledgements

This work forms part of the platform for the European preparedness against (re-)emerging epidemics (PREPARE) Work Package 2. PREPARE is funded by the European Commission's FP7 Programme grant number 602525. This research was partially funded by the University Of North Carolina School Of Medicine International Health Fellowship Award.