Journal article

Interleukin-8 Predicts Fatigue at 12 Months Post-Injury in Children with Traumatic Brain Injury

Alison Crichton, Vera Ignjatovic, Franz E Babl, Ed Oakley, Mardee Greenham, Stephen Hearps, Carmel Delzoppo, Miriam H Beauchamp, Anne-Marie Guerguerian, Kathy Boutis, Evyatar Hubara, Jamie Hutchison, Vicki Anderson

JOURNAL OF NEUROTRAUMA | MARY ANN LIEBERT, INC | Published : 2021

Abstract

Despite many children experiencing fatigue after childhood brain injury, little is known about the predictors of this complaint. To date, traditional indices of traumatic brain injury (TBI) severity have not predicted reliably persisting fatigue (up to three years post-injury). This study aimed to establish whether persisting fatigue is predicted by serum biomarker concentrations in child TBI. We examined whether acute serum biomarker expression would improve prediction models of 12-month fatigue based on injury severity. Blood samples were collected from 87 children (1-17 years at injury) sustaining mild to severe TBI (Glasgow Coma Scale [GCS] range 3-15; mean 12.43; classified as mild TBI ..

View full abstract