Bystander Activation of Pulmonary Trm Cells Attenuates the Severity of Bacterial Pneumonia by Enhancing Neutrophil Recruitment
Chenghao Ge, Ian R Monk, Angela Pizzolla, Nancy Wang, James G Bedford, Timothy P Stinear, Glen P Westall, Linda M Wakim
CELL REPORTS | CELL PRESS | Published : 2019
Tissue-resident memory T (Trm) cells are described as having a "sensing and alarming" function, meaning they can rapidly release cytokines in response to local cognate antigen recognition, which in turn, draws circulating immune cells into the tissue. Here, we show noncognate, bystander activation can also trigger the sensing and alarming function of pulmonary CD8+ Trm cells. Virus-specific CD8+ Trm cells lodged in the lung parenchyma, but not memory CD8+ T cells located in the vasculature, rapidly synthesize interferon γ (IFN-γ) following the inhalation of heat-killed bacteria or bacterial products, a process driven by interleukin-12 (IL-12)/IL-18 exposure. We show that a respiratory bacter..View full abstract
We thank Prof. William Heath for helpful discussions. L.M.W. was supported by National Health and Medical Research Council (NHMRC) of Australia and Australian Research Council (ARC) grants, and C.G. was supported by the China Scholarship Council.