Conference Proceedings
Heritable methylation marks associated with breast cancer risk
Melissa C Southey, Jihoon E Joo, James G Dowty, Roger L Milne, EE Ming Wong, Pierre-Antoine Dugue, Dallas English, John L Hopper, Daivd E Goldgar, Graham G Giles
CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2017
Abstract
Abstract While most epigenetic marks are reprogrammed during early embryogenesis, some studies have reported Mendelian-like inheritance of germline DNA methylation in particular cancer susceptibility genes. We aimed to identify heritable methylation marks associated with breast cancer susceptibility by studying 25 Australian multi-generational families with multiple cases of breast cancer who were not known to carry mutations in breast cancer susceptibility genes. Peripheral blood DNA methylation was measured at approximately 480,000 genetic loci (methylation sites) for 210 members of these families using the Infinium HumanMethylation450 BeadArray. We developed and applied a n..
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