Journal article

Regression of cardiac hypertrophy normalizes glucose metabolism and left ventricular function during reperfusion

RB Wambolt, SL Henning, DR English, GP Bondy, MF Allard

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 1997

Abstract

It is not yet known if the alterations in myocardial glucose metabolism and the exaggerated left ventricular dysfunction that occur during reperfusion in hypertrophied hearts are reversible. Thus, we studied isolated working hearts from aortic-banded (n = 29) and sham-operated control (n = 32) male Sprague-Dawley rats with or without enalapril maleate treatment (25.6 +/- 0.8 mg/kg per day, p.o.) to determine the effect of regression of cardiac hypertrophy on myocardial glucose metabolism and post-ischemic heart function. Hearts were perfused with buffer containing 1.2 mM palmitate, 11 mM [5-3H]/[U-14C]-glucose, 0.5 mM lactate and 100 microU/ml insulin. Glucose metabolism [rates of glycolysis..

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