Journal article
Application of Urine-Derived Stem Cells to Cellular Modeling in Neuromuscular and Neurodegenerative Diseases
M Sato, H Takizawa, A Nakamura, BJ Turner, F Shabanpoor, Y Aoki
Frontiers in Molecular Neuroscience | FRONTIERS MEDIA SA | Published : 2019
Open access
Abstract
Neuromuscular and neurodegenerative diseases are mostly modeled using genetically modified animals such as mice. However, animal models do not recapitulate all the phenotypes that are specific to human disease. This is mainly due to the genetic, anatomical and physiological difference in the neuromuscular systems of animals and humans. The emergence of direct and indirect human somatic cell reprogramming technologies may overcome this limitation because they enable the use of disease and patient-specific cellular models as enhanced platforms for drug discovery and autologous cell-based therapy. Induced pluripotent stem cells (iPSCs) and urine-derived stem cells (USCs) are increasingly employ..
View full abstractGrants
Awarded by Japan Agency for Medical Research and Development
Funding Acknowledgements
This work was supported by a Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research (C) (Grant No. 18K07544 to YA), Grants-in-Aid for Research on Nervous and Mental Disorders (Grant No. 28-6 to YA), and the Japan Agency for Medical Research and Development (Grant No. 18ek0109239h0002, 18lm0203066h0001, and 18lm0203069h0001 to YA) and an Australian NHMRC-ARC Dementia Research Leadership Fellowship (APP1137024 to BT).