Journal article

Accumulation of CD103( ) CD8( ) T cells in a cutaneous melanoma micrometastasis

Katharina Hochheiser, Han Xian Aw Yeang, Teagan Wagner, Candani Tutuka, Andreas Behren, Jason Waithman, Christopher Angel, Paul J Neeson, Thomas Gebhardt, David E Gyorki

Clinical & Translational Immunology | WILEY | Published : 2019

Abstract

Objective: The immune system can halt cancer progression by suppressing outgrowth of clinically occult micrometastases in a state of cancer-immune equilibrium. Cutaneous melanoma provides a unique opportunity to study the immune contexture of such lesions, as miniscule skin metastases are accessible to clinical inspection and diagnostic biopsy. Methods: Here, we analysed by multiplex immunofluorescence microscopy samples from a melanoma patient presenting with an overt and an occult in-transit metastasis (ITM), the latter of which appeared as a small erythematous papule. Results: Microarchitecture and immune composition in the two lesions were vastly different. CD4+ and CD8+ T cells accumula..

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Grants

Awarded by Cancer Council of Victoria


Funding Acknowledgements

KH is the Rhian and Paul Brazis Fellow in Translational Melanoma Immunology administered by the Peter MacCallum Cancer Foundation. TG is a Senior Biomedical Research Fellow supported by the Sylvia and Charles Viertel Charitable Foundation. AB is the recipient of a Fellowship from the Victorian Government Department of Health and Human Services acting through the Victorian Cancer Agency. JW is supported by a Cancer Council Western Australia Fellowship. This work was supported by a grant-in-aid by the Cancer Council of Victoria (APP1163465 to TG).