Accumulation of CD103( ) CD8( ) T cells in a cutaneous melanoma micrometastasis
Katharina Hochheiser, Han Xian Aw Yeang, Teagan Wagner, Candani Tutuka, Andreas Behren, Jason Waithman, Christopher Angel, Paul J Neeson, Thomas Gebhardt, David E Gyorki
Clinical & Translational Immunology | WILEY | Published : 2019
Objective: The immune system can halt cancer progression by suppressing outgrowth of clinically occult micrometastases in a state of cancer-immune equilibrium. Cutaneous melanoma provides a unique opportunity to study the immune contexture of such lesions, as miniscule skin metastases are accessible to clinical inspection and diagnostic biopsy. Methods: Here, we analysed by multiplex immunofluorescence microscopy samples from a melanoma patient presenting with an overt and an occult in-transit metastasis (ITM), the latter of which appeared as a small erythematous papule. Results: Microarchitecture and immune composition in the two lesions were vastly different. CD4+ and CD8+ T cells accumula..View full abstract
Awarded by Cancer Council of Victoria
KH is the Rhian and Paul Brazis Fellow in Translational Melanoma Immunology administered by the Peter MacCallum Cancer Foundation. TG is a Senior Biomedical Research Fellow supported by the Sylvia and Charles Viertel Charitable Foundation. AB is the recipient of a Fellowship from the Victorian Government Department of Health and Human Services acting through the Victorian Cancer Agency. JW is supported by a Cancer Council Western Australia Fellowship. This work was supported by a grant-in-aid by the Cancer Council of Victoria (APP1163465 to TG).