Influence of Comorbidity of Cerebrovascular Disease and Amyloid-beta on Alzheimer's Disease

Nawaf Yassi; Saima Hilal; Ying Xia; Yen Ying Lim; Rosie Watson; Hugo Kuijf; Christopher Fowler; Paul Yates; Paul Maruff; Ralph Martins; David Ames; Christopher Chen; Christopher C Rowe; Victor L Villemagne; Olivier Salvado; Patricia M Desmond; Colin L Masters

Journal article

Influence of Comorbidity of Cerebrovascular Disease and Amyloid-beta on Alzheimer's Disease

Nawaf Yassi, Saima Hilal, Ying Xia, Yen Ying Lim, Rosie Watson, Hugo Kuijf, Christopher Fowler, Paul Yates, Paul Maruff, Ralph Martins, David Ames, Christopher Chen, Christopher C Rowe, Victor L Villemagne, Olivier Salvado, Patricia M Desmond, Colin L Masters

Journal of Alzheimer's Disease | IOS PRESS | Published : 2020

DOI: 10.3233/JAD-191028

Abstract

BACKGROUND: Quantifying the contribution of cerebrovascular disease to the clinical and pathological profile of Alzheimer's disease is challenging. OBJECTIVE: We aimed to determine the influence of cerebrovascular disease, amyloid-β (Aβ), and their comorbidity on cognitive decline, hippocampal atrophy, and Aβ deposition, by evaluating data from the Australian Imaging, Biomarker and Lifestyle Study of Ageing. METHODS: Two-hundred and eighteen participants underwent Aβ PET, MRI, and cognitive assessment at 18-month intervals for up to 90 months. Aβ status was determined on baseline PET. Participants were also classified as V+ on baseline MRI if they had≥1 large cortical infarcts, subcortical i..

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University of Melbourne Researchers

Yen Ying Lim Author Florey Department of Neuroscience and Mental Health

Nawaf Yassi Author Medicine - Royal Melbourne Hospital

Colin Masters Author Florey Department of Neuroscience and Mental Health

Rosie Watson Author Medicine - Royal Melbourne Hospital

Christopher Rowe Author Florey Department of Neuroscience and Mental Health

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

The AIBL study (http://www.AIBL.csiro.au) is a consortium between Austin Health, CSIRO, Edith Cowan University, the Florey Institute (The University of Melbourne), and the National Ageing Research Institute. Partial financial support provided by the Alzheimer's Association (US), the Alzheimer's Drug Discovery Foundation, an Anonymous foundation, the Science and Industry Endowment Fund, the Dementia Collaborative Research Centres, the Victorian Government's Operational Infrastructure Support program, the McCusker Alzheimer's Research Foundation, the National Health and Medical Research Council, and the Yulgilbar Foundation. Numerous commercial interactions have supported data collection and analysis. In-kind support has also been provided by Sir Charles Gairdner Hospital, CogState Ltd., Hollywood Private Hospital, the University of Melbourne, and St Vincent's Hospital.NY is funded by a National Health and Medical Research Council - Australian Research Council Dementia Research Fellowship.YYL reports funds from the National Health and Medical Research Council (GNT 111603, GNT1147465).