The need to incorporate aged animals into the preclinical modeling of neurological conditions
Mujun Sun, Stuart J McDonald, Rhys D Brady, Lyndsey Collins-Praino, Glenn R Yamakawa, Mastura Monif, Terence J O'Brien, Geoffrey C Cloud, Christopher G Sobey, Richelle Mychasiuk, David J Loane, Sandy R Shultz
Neuroscience & Biobehavioral Reviews | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2020
Neurological conditions such as traumatic brain injury, stroke, Parkinson's disease, epilepsy, multiple sclerosis, and Alzheimer's disease are serious clinical problems that affect millions of people worldwide. The majority of clinical trials for these common conditions have failed, and there is a critical need to understand why treatments in preclinical animal models do not translate to patients. Many patients with these conditions are middle-aged or older, however, the majority of preclinical studies have used only young-adult animals. Considering that aging involves biological changes that are relevant to the pathobiology of neurological diseases, the lack of aged subjects in preclinical ..View full abstract
Awarded by National Health and Medical Research Council of Australia
SRS is supported by a fellowship from the National Health and Medical Research Council of Australia (#1159645).