Preferential Neurodegeneration in the Dentate Gyrus by Amyloid β1–42-Induced Intracellular Zn2 Dysregulation and Its Defense Strategy

Abstract

On the basis of the evidence that rapid intracellular Zn2+ dysregulation by amyloid β1–42 (Aβ1–42) in the normal hippocampus transiently induces cognitive decline, here we report preferential neurodegeneration in the dentate gyrus by Aβ1–42-induced intracellular Zn2+ dysregulation and its defense strategy. Neurodegeneration was preferentially observed in the dentate granule cell layer in the hippocampus after a single Aβ1–42 injection into the lateral ventricle but not in the CA1 and CA3 pyramidal cell layers, while intracellular Zn2+ dysregulation was extensively observed in the hippocampus in addition to the dentate gyrus. Neurodegeneration in the dentate granule cell layer was rescued aft..