Journal article

Preferential Neurodegeneration in the Dentate Gyrus by Amyloid beta(1-42)-Induced Intracellular Zn(2 )Dysregulation and Its Defense Strategy

Haruna Tamano, Mako Takiguchi, Yukino Tanaka, Taku Murakami, Paul A Adlard, Ashley I Bush, Atsushi Takeda

Molecular Neurobiology | SPRINGER | Published : 2020

Abstract

On the basis of the evidence that rapid intracellular Zn2+ dysregulation by amyloid β1-42 (Aβ1-42) in the normal hippocampus transiently induces cognitive decline, here we report preferential neurodegeneration in the dentate gyrus by Aβ1-42-induced intracellular Zn2+ dysregulation and its defense strategy. Neurodegeneration was preferentially observed in the dentate granule cell layer in the hippocampus after a single Aβ1-42 injection into the lateral ventricle but not in the CA1 and CA3 pyramidal cell layers, while intracellular Zn2+ dysregulation was extensively observed in the hippocampus in addition to the dentate gyrus. Neurodegeneration in the dentate granule cell layer was rescued aft..

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