Alcohol Abstinence in Drinkers with Atrial Fibrillation
Aleksandr Voskoboinik, Jonathan M Kalman, Anurika De Silva, Thomas Nicholls, Benedict Costello, Shane Nanayakkara, Sandeep Prabhu, Dion Stub, Sonia Azzopardi, Donna Vizi, Geoffrey Wong, Chrishan Nalliah, Hariharan Sugumar, Michael Wong, Emily Kotschet, David Kaye, Andrew J Taylor, Peter M Kistler
New England Journal of Medicine | MASSACHUSETTS MEDICAL SOC | Published : 2020
BACKGROUND: Excessive alcohol consumption is associated with incident atrial fibrillation and adverse atrial remodeling; however, the effect of abstinence from alcohol on secondary prevention of atrial fibrillation is unclear. METHODS: We conducted a multicenter, prospective, open-label, randomized, controlled trial at six hospitals in Australia. Adults who consumed 10 or more standard drinks (with 1 standard drink containing approximately 12 g of pure alcohol) per week and who had paroxysmal or persistent atrial fibrillation in sinus rhythm at baseline were randomly assigned in a 1:1 ratio to either abstain from alcohol or continue their usual alcohol consumption. The two primary end points..View full abstract
Supported in part by the Government of Victoria Operational Infrastructure Support Program. Dr. Voskoboinik is the recipient of postgraduate scholarships cofunded by the National Health and Medical Research Council (NHMRC) and National Heart Foundation and Baker Institute Bright Sparks scholarships; Dr. Kalman, a NHMRC practitioner fellowship; and Dr. Stub, a National Heart Foundation Early Career Fellowship and Viertel Foundation Award. Alive Technologies provided a 20% discount for AliveCor Kardia Mobile EKG monitors.