Journal article

Diarrhoeal disease and subsequent risk of death in infants and children residing in low-income and middle-income countries: analysis of the GEMS case-control study and 12-month GEMS-1A follow-on study

Myron M Levine, Dilruba Nasrin, Sozinho Acacio, Quique Bassat, Helen Powell, Sharon M Tennant, Samba O Sow, Dipika Sur, Anita KM Zaidi, Abu SG Faruque, M Jahangir Hossain, Pedro L Alonso, Robert F Breiman, Ciara E O'Reilly, Eric D Mintz, Richard Omore, John B Ochieng, Joseph O Oundo, Boubou Tamboura, Doh Sanogo Show all

The Lancet Global Health | ELSEVIER SCI LTD | Published : 2020


BACKGROUND: The Global Enteric Multicenter Study (GEMS) was a 3-year case-control study that measured the burden, aetiology, and consequences of moderate-to-severe diarrhoea (MSD) in children aged 0-59 months. GEMS-1A, a 12-month follow-on study, comprised two parallel case-control studies, one assessing MSD and the other less-severe diarrhoea (LSD). In this report, we analyse the risk of death with each diarrhoea type and the specific pathogens associated with fatal outcomes. METHODS: GEMS was a prospective, age-stratified, matched case-control study done at seven sites in Africa and Asia. Children aged 0-59 months with MSD seeking care at sentinel health centres were recruited along with o..

View full abstract


Awarded by Bill & Melinda Gates Foundation

Funding Acknowledgements

This study was supported by grants 38874 and OPP1033572 from the Bill & Melinda Gates Foundation (MML, Principal lnvestigator). MML is supported in part by the Simon and Bessie Grollman Distinguished Professorship. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.