Defining benefit threshold for extracorporeal membrane oxygenation in children with sepsis-a binational multicenter cohort study
Luregn J Schlapbach, Roberto Chilettr, Lahn Straney, Marino Festa, Daniel Alexander, Warwick Butt, Graeme MacLaren, Anusha Ganeshalingam, Claire Sherring, Simon Erickson, Samantha Barr, Andreas Schibler, Debbie Long, Luregn Schlapbach, Jan Alexander, Shane George, Gary Williams, Vicky Smith, Carmel Delzoppo, Johnny Millar Show all
CRITICAL CARE | BMC | Published : 2019
BACKGROUND: The surviving sepsis campaign recommends consideration for extracorporeal membrane oxygenation (ECMO) in refractory septic shock. We aimed to define the benefit threshold of ECMO in pediatric septic shock. METHODS: Retrospective binational multicenter cohort study of all ICUs contributing to the Australian and New Zealand Paediatric Intensive Care Registry. We included patients < 16 years admitted to ICU with sepsis and septic shock between 2002 and 2016. Sepsis-specific risk-adjusted models to establish ECMO benefit thresholds with mortality as the primary outcome were performed. Models were based on clinical variables available early after admission to ICU. Multivariate analyse..View full abstract
LJS is supported by a Practitioner Fellowship of the National Health and Medical Research Council of Australia and New Zealand and by the Children's Hospital Foundation, Brisbane, Australia.