Digital ulcers in systemic sclerosis: their epidemiology, clinical characteristics, and associated clinical and economic burden
Kathleen Morrisroe, Wendy Stevens, Joanne Sahhar, Gene-Siew Ngian, Nava Ferdowsi, Catherine L Hill, Janet Roddy, Jennifer Walker, Susanna Proudman, Mandana Nikpour
Arthritis Research and Therapy | BMC | Published : 2019
BACKGROUND: To determine the frequency and clinical characteristics of systemic sclerosis-related digital ulcers, and associated direct health care costs, quality of life, and survival. METHODS: Digital ulcers (DUs) were defined as an area with a visually discernible depth and a loss of continuity of epithelial coverage. DU severity was calculated based on the physician reported highest number of new DUs at clinical review (mild = 1-5 DUs, moderate 6-10 DUs, severe > 10 DUs). Healthcare use was captured through data linkage, wherein SSc clinical data captured prospectively in a dedicated clinical database were linked with health services databases to capture hospital admissions, emergency de..View full abstract
Awarded by National Health and Medical Research Council of Australia
This work was supported by Scleroderma Australia, Arthritis Australia, Actelion Australia, Bayer, CSL Biotherapies, GlaxoSmithKline Australia, and Pfizer. KM was supported by Arthritis Australia Fellowship. MN holds a National Health and Medical Research Council of Australia Career Development Fellowship (APP 1126370).