Journal article

Uptake of polygenic risk information among women at increased risk of breast cancer

Tatiane Yanes, Bettina Meiser, Rajneesh Kaur, Maatje Scheepers-Joynt, Simone McInerny, Shelby Taylor, Kristine Barlow-Stewart, Yoland Antill, Lucinda Salmon, Courtney Smyth, Mary-Anne Young, Paul A James

Clinical Genetics | WILEY | Published : 2019

Abstract

Polygenic risk scores (PRSs) are increasingly being implemented to assess breast cancer risk. This study aimed to assess and determine factors associated with uptake of PRS among women at increased risk of breast cancer for whom genetic testing to date had been uninformative. Participants were recruited from the Variants in Practice study from which breast cancer PRS had been calculated. Four hundred women were notified by letter of the availability of their PRS and invited to complete a self-administered survey comprising several validated scales. Considering non-participants, uptake of PRS was between 61.8% and 42.1%. Multivariate logistic regression identified that women were more likely ..

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Grants

Awarded by Cancer Council of New South Wales


Awarded by National Health and Medical Research Council


Funding Acknowledgements

Cancer Council of New South Wales, Grant/Award Number: 1079897; National Health and Medical Research Council, Grant/Award Numbers: 1078523, 1133049; Translational Cancer Research Institute PhD Top-up Scholarship