Journal article

Exercise improves metabolic function and alters the microbiome in rats with gestational diabetes

Dayana Mahizir, Jessica F Briffa, Jennifer L Wood, Kristina Anevska, Elisa L Hill-Yardin, Andrew J Jefferies, Sogand Gravina, Gisella Mazzarino, Ashley E Franks, Karen M Moritz, Glenn D Wadley, Mary E Wlodek

The FASEB Journal | FEDERATION AMER SOC EXP BIOL | Published : 2020

Abstract

Gestational diabetes mellitus (GDM) is a common pregnancy complication, particularly prevalent in obese women. Importantly, exercise has beneficial impacts on maternal glucose control and may prevent GDM in "at-risk" women. We aimed to determine whether a high-fat diet (HFD) exacerbates metabolic dysfunction and alters gut microbiome in GDM and whether endurance exercise prevents these changes. Uteroplacental insufficiency was induced by bilateral uterine vessel ligation (Restricted) or sham (Control) surgery on E18 in Wistar-Kyoto rats. Female offspring were fed a Chow or HFD (23% fat) from weaning (5 weeks) and at 16 weeks randomly allocated to remain Sedentary or to an exercise protocol o..

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