Journal article

Evidence that alpha blocking is due to increases in system-level oscillatory damping not neuronal population desynchronisation

David TJ Liley, Suresh D Muthukumaraswamy

NeuroImage | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2020

Abstract

The attenuation of the alpha rhythm following eyes-opening (alpha blocking) is among the most robust features of the human electroencephalogram with the prevailing view being that it is caused by changes in neuronal population synchrony. To further study the basis for this phenomenon we use theoretically motivated fixed-order Auto-Regressive Moving-Average (ARMA) time series modelling to study the oscillatory dynamics of spontaneous alpha-band electroencephalographic activity in eyes-open and eyes-closed conditions and its modulation by the NMDA antagonist ketamine. We find that the reduction in alpha-band power between eyes-closed and eyes-open states is explicable in terms of an increase i..

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Grants

Funding Acknowledgements

We thank Anna Forsyth and Rebecca McMillan (University of Auckland) for help in data collection and pre-processing. Juergen Dukart and Jorg Hipp (Roche Pharma Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases, Roche Innovation Centre, Basel, Switzerland) kindly advised on aspects of data pre-processing and collection. The data analysed in this paper was funded by a grant from F Hoffman La Roche Ltd.