Host-mediated impairment of parasite maturation during blood-stage Plasmodium infection
David S Khoury, Deborah Cromer, Jasmin Akter, Ismail Sebina, Trish Elliott, Bryce S Thomas, Megan SF Soon, Kylie R James, Shannon E Best, Ashraful Haque, Miles P Davenport
Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD SCIENCES | Published : 2017
Severe malaria and associated high parasite burdens occur more frequently in humans lacking robust adaptive immunity to Plasmodium falciparum Nevertheless, the host may partly control blood-stage parasite numbers while adaptive immunity is gradually established. Parasite control has typically been attributed to enhanced removal of parasites by the host, although in vivo quantification of this phenomenon remains challenging. We used a unique in vivo approach to determine the fate of a single cohort of semisynchronous, Plasmodium berghei ANKA- or Plasmodium yoelii 17XNL-parasitized red blood cells (pRBCs) after transfusion into naive or acutely infected mice. As previously shown, acutely infec..View full abstract
Awarded by Australian Research Council
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by Australian NHMRC
This work was supported by the Australian Research Council (Grant DP120100064) and the National Health and Medical Research Council (NH&MRC) (Grant 1082022 to M.P.D., D.C., and A.H.; Grant 1080001 to M.P.D.; and Grants 1028634 and 1028641 to A.H.). The Australian Federal Government provided Australian Postgraduate awards (to D.S.K. and K.R.J.). The University of Queensland (UQ) provided International Postgraduate Research scholarships (to I.S. and J.A.) and a UQ Advantage grant (to I.S.). M.S.F.S. and S.E.B. were supported by Australian NH&MRC Project Grants 613702 and 1028641.