Reduced erythrocyte susceptibility and increased host clearance of young parasites slows Plasmodium growth in a murine model of severe malaria
David S Khoury, Deborah Cromer, Shannon E Best, Kylie R James, Ismail Sebina, Ashraful Haque, Miles P Davenport
Scientific Reports | NATURE PUBLISHING GROUP | Published : 2015
The best correlate of malaria severity in human Plasmodium falciparum (Pf) infection is the total parasite load. Pf-infected humans could control parasite loads by two mechanisms, either decreasing parasite multiplication, or increasing parasite clearance. However, few studies have directly measured these two mechanisms in vivo. Here, we have directly quantified host clearance of parasites during Plasmodium infection in mice. We transferred labelled red blood cells (RBCs) from Plasmodium infected donors into uninfected and infected recipients, and tracked the fate of donor parasites by frequent blood sampling. We then applied age-based mathematical models to characterise parasite clearance i..View full abstract
Awarded by Australian NH&MRC Project Grants
D.S.K. is supported by an Australian Postgraduate Award. D.C. is a UNSW Vice-Chancellor's Post-Doctoral Fellow. S.E.B. is funded by Australian NH&MRC Project Grants (Grant Numbers 613702 and 1028641). K.R.J. is funded by Australian NH&MRC Project Grants (Grant Number 1028641). I.S. is funded by Australian NH&MRC Project Grants (Grant Number 1028641). A.H. is an Australian NH&MRC Career Development Fellow. M.P.D. is an NH&MRC Senior Research Fellow (Grant Number 630542). The work was funded by the ARC, NH&MRC and QIMR Berghofer Centre for Immunotherapy and Vaccine Development.