Journal article

Critical role of type 1 cytokines in controlling initial infection with Burkholderia mallei

Caroline A Rowland, Ganjana Lertmemongkolchai, Alison Bancroft, Ashraful Haque, M Stephen Lever, Kate F Griffin, Matthew C Jackson, Michelle Nelson, Anne O'Garra, Richard Grencis, Gregory J Bancroft, Roman A Lukaszewski

INFECTION AND IMMUNITY | AMER SOC MICROBIOLOGY | Published : 2006

Abstract

Burkholderia mallei is a gram-negative bacterium which causes the potentially fatal disease glanders in humans; however, there is little information concerning cell-mediated immunity to this pathogen. The role of gamma interferon (IFN-gamma) during B. mallei infection was investigated using a disease model in which infected BALB/c mice normally die between 40 and 60 days postinfection. IFN-gamma knockout mice infected with B. mallei died within 2 to 3 days after infection, and there was uncontrolled bacterial replication in several organs, demonstrating the essential role of IFN-gamma in the innate immune response to this pathogen. Increased levels of IFN-gamma, interleukin-6 (IL-6), and mon..

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University of Melbourne Researchers