Angiotensin II and aldosterone activate retinal microglia
Indrajeetsinh Rana, Varaporn Suphapimol, Jack R Jerome, Dean M Talia, Devy Deliyanti, Jennifer L Wilkinson-Berka
Experimental Eye Research | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2020
Microglial cells are important contributors to the neuroinflammation and blood vessel damage that occurs in ischemic retinopathies. We hypothesized that key effectors of the renin-angiotensin aldosterone system, angiotensin II (Ang II) and aldosterone, increase the density of microglia in the retina and stimulate their production of reactive oxygen species (ROS) as well as pro-angiogenic and pro-inflammatory factors. Two animal models were studied that featured up-regulation of Ang II or aldosterone and included transgenic Ren-2 rats which overexpress renin and Ang II in tissues including the retina, and Sprague Dawley rats with ischemic retinopathy and infused with aldosterone. Complementar..View full abstract
Awarded by National Health and Medical Research Council of Australia
The work was supported by the National Health and Medical Research Council of Australia (Grant number 1078442). The authors have no conflict of interest to declare. DD is a post-doctoral fellow of the Juvenile Diabetes Research Foundation (New York, USA).